Effect of oral administration of methanol leaf extract of Terminalia catappa (Tropical Almond) on serum hepato-markers
1 Department of Human Physiology, Gregory University, Uturu Abia State, Nigeria.
2 Department of Human Anatomy, Chukwuemeka Odumekwu Ojukwu University, Uli, Nigeria.
3 Department of Human Physiology, College of Medicine and Health Sciences, Abia State University, Uturu Nigeria.
4 Department of Pediatrics, Federal Medical Centre, Owerri, Imo State, Nigeria.
Research Article
International Journal of Frontline Research in Pharma and Bio Sciences, 2023, 02(01), 001–004.
Article DOI: 10.56355/ijfrpbs.2023.2.1.0015
Publication history:
Received on 04 February 2023; revised on 30 March 2023; accepted on 01 April 2023
Abstract:
The aim of this study was to evaluate the effect of methanol leaf extract of Terminalia catappa. Freshly harvested leaves of T. catappa were washed, dried and ground into fine powder. The powdered plant sample was processed into extract. Twenty five adult male wistar rats were divided into five groups of five rats. Group I: was the normal control fed only with rat chow and water, Groups II-V were administered with 100, 200, 400 and 600 mg/kg of methanol leaf extract of Terminalia catappa (MLETC). Treatment lasted for 28 days, after which animals were sacrificed and blood sample collected analysed using standard procedures. The result obtained showed that oral administration of extract significantly (P<0.05) increased the activity of liver enzyme in a dose dependent manner. This may or may not necessarily imply that the extract is hepatotoxic as certain compounds can induce the said enzymes and may not mean that the liver is damaged.
Keywords:
Terminalia catappa; Liver; Hepatotoxic; Blood
Full text article in PDF:
Copyright information:
Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0