Gastrointestinal and renal regulation of calcium metabolism
Department of Chemical pathology, Federal Medical Center Makurdi, Nigeria.
Review
International Journal of Frontline Research in Life Science, 2022, 01(01), 005–023.
Article DOI: 10.56355/ijfrls.2022.1.1.0003
Publication history:
Received on 08 February 2022; revised on 30 March 2022; accepted on 01 April 2022
Abstract:
Calcium is critical to human physiology for the function of excitable tissues (e.g. neuromuscular function) and is also needed for skeletal mineralization. The maintenance of a constant free ionized calcium concentration is biologically important for these functions. Regulation of calcium levels is a pre-requisite for its maintenance. In this article, calcium homeostasis is reviewed in respect to the critical organs involved; gastrointestinal tract, and the kidneys. Also reviewed is the calcium sensing receptor (CaSR) which serve as a calcium regulator (calciostat) in calciotropic tissues and regulates other biological functions in non-calciotropic tissues. The purpose of this review is to discuss the normal regulation of calcium metabolism in order to provide the clinician with basic information for the diagnosis and therapeutic management of calcium metabolism disorders as well as related pathologies.
Keywords:
Calcium; Gastrointestinal; Renal; calcium sensing receptor
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Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0